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SIIA Público
SISTEMA INTEGRAL DE INFORMACIÓN ACADÉMICA - PÚBLICO
Título del libro: Technical Proceedings Of The 2014 Nsti Nanotechnology Conference And Expo, Nsti-Nanotech 2014 Título del capítulo: Cu/TiO2-SiO2 nanostructured materials for brain cancer treatment
Biocompatibility; Cell death; Copper; Cytotoxicity; Diseases; Fluidics; Medical nanotechnology; Nanostructured materials; Photonics; Rats; Sol-gels; Titanium compounds; Ultraviolet visible spectroscopy; Binary oxides; Brain cancer; Copper complexes; IR and UV-Vis spectroscopies; Mitochondrial fragmentation; Original structures; Physicochemical techniques; Synthesis procedure; Nanotechnology
Resumen:
In the present work, we report the toxic effect exerted on glioblastoma cells of rat (C6 line) by copper complexes released from a binary oxide (TiO2-SiO2=TISI). Individually, copper acetylacetonate and ammonium tetrachlorocuprate were added to the oxide during its synthesis procedure using the sol-gel methodology. Several physicochemical techniques were used to characterize the resulting materials. The cell viability was determined by the colorimetric MTT assay. The results of IR and UV-VIS spectroscopies indicate that copper complexes maintained their original structure after being loaded in the oxide. Cell viability results showed high cytotoxic effect of the copper complexes as well as those released from TISI. Pure TISI did not exert cytotoxicity to the C6 cells, indicating its high biocompatibility. Although, COS-7 cells are not cancer cells from the rat brain, these served to determine that a mitochondrial fragmentation (apoptosis) occurred when these cells were treated with Cu(acac)2-TISI during 12 h.
Entidades citadas de la UNAM:
Fuente:
ISBN: 9781482258271 Editorial: Nano Science and Technology Institute
