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Título del libro: Molecular Oncology Principles And Recent Advances
Título del capítulo: Chemotherapy and design of new antineoplastic compounds

Autores UNAM:
CLAUDIA RIVERA GUEVARA; MARIA ELENA BRAVO GOMEZ; LENA RUIZ AZUARA;
Autores externos:

Idioma:
Inglés
Año de publicación:
2012
Palabras clave:

Antineoplastic; Bioinorganic chemistry; Casiopeínas®; Chemotherapy; Copper compounds; Drug design; Drug develop; Drug testing; Medicinal chemistry; Metal compounds


Resumen:

The successful use of chemotherapy in the treatment of several diseases has been one of the great drug development stories of the last century. Motivated by this, we present here an overview of the various steps required to develop a new drug treatment. An introductory view of the field of medicinal chemistry is provided as an example to a broad discipline that has successfully designed procedures that are routinely used for drug development. A detailed view of the subfield of bioinorganic medicinal chemistry is then presented which describes the research and development involved in the design of new metal-based drugs. A specific example of the development of the CASIOPEINAS- family compounds, a set of copper based molecules is used to illustrate the wide range of strict scientific procedures involved from initial design to the final registration of the drug. © 2012 Bentham Science Publishers. All rights reserved.


Entidades citadas de la UNAM: