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Título del libro: Nuts And Seeds In Health And Disease Prevention
Título del capítulo: Soursop (Annona muricata L.) Seeds, Therapeutic and Possible Food Potential

Autores UNAM:
MARIA DEL CARMEN BAZUA DURAN;
Autores externos:

Idioma:
Inglés
Año de publicación:
2011
Resumen:

This chapter highlights the therapeutic potential of soursop seeds. Scientific studies have confirmed the presence of alkaloids, acetogenins, and cyclopeptides, compounds of great importance in these seeds that have attracted pharmacological interest. The seeds also contain a significant amount of oil, the composition and physical and chemical properties of which make it potentially attractive in the food sector. Various pharmacological investigations have shown that these metabolites possess antitumor, antidiarrheal, larvicidal, antimalarial, pesticidal, and fungicidal activities, especially with regard to their antitumor properties in vitro. Some are among the most potent inhibitors of complex I (NADH: ubiquinone oxidoreductase) in the system of mitochondrial electron transport between the said complex and the NADH-oxidase in the plasma membrane characteristic of cancer cells; these actions induce apoptosis (programmed cell death), perhaps following deprivation of ATP. Annonaceous acetogenins are the most studied bioactive metabolites from Annona muricata seeds and have high cytotoxic activity with potential therapeutic applications. Other important components of the Annona muricata seeds have also been studied from a food perspective. Any component derived from Annona muricata seeds for alimentary consumption must be studied regarding possible toxicological risks. © 2011 Copyright © 2011 Elsevier Inc. All rights reserved..


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