Character; First-episode schizophrenia; Personality; Symptom expression.; Temperament
Introduction Personality and psychopathology are aspects of human existence that have been recognized across times and cultures as having a mutual connection. Since Bleuler and Kraepelin, premorbid specific personality features and progressive deterioration of personality in patients with schizophrenia were described. Personality is one form of individual difference that may affect schizophrenic symptom expression by means of an underlying psychophysiology. The psychobiological model proposed by Cloninger has been suggested as particularly relevant in schizophrenia since there is empirical evidence that each of the temperamental dimensions reflect the regulation of brain activity by distinct neurotransmitter systems which are also involved in schizophrenic symptom expression, while abnormalities of character development may affect cognitive and behavioral adaptation of schizophrenic patients. Objective The present study aims (a) to determine the reliability of the temperament and character dimensions in a sample of Mexican first-episode schizophrenic patients and healthy controls, (b) to compare temperament and character dimensions between first-episode schizophrenic patients and healthy controls, and (b) to explore the associations between these personality dimensions with the five-factor structure of the PANSS. Method A total of 94 patients with schizophrenia from the National Institute of Psychiatry (NIP) in Mexico City were recruited. They were on their first psychiatric admission due to psychosis. Patients were excluded if they had been treated for a period longer than a month with an equivalent dose of 5 mg/day of haloperidol. One-hundred healthy controls were recruited. Symptom severity in patients was rated using the dimensional models of schizophrenic symptoms, based on a 5 factor analysis of the Positive and Negative Syndrome Scale (PANSS) and personality was assessed in patients and healthy controls using the Temperament and Character Inventory (TCI). Results The seven personality dimensions showed moderate to high reliability in first-episode schizophrenic patients and healthy controls. With respect to temperament dimensions, patients exhibited higher harm avoidance and lower reward dependence when compared to healthy controls. The scores of the character dimensions self-directedness and cooperativeness were higher in the control group. Novelty seeking was associated with positive and excitement symptom severity, while harm avoidance was related to negative symptom severity. The character dimension cooperativeness was associated with more severe anxiety/depressive symptoms in first-episode schizophrenic patients. Conclusions Our findings strengthen the hypothesis that personality differences are detectable among persons with first-episode schizophrenia revealing an abnormal structure of personality. Also, symptom dimensions can be conceptualised partly as manifestations of personality in first-episode schizophrenia. Psychiatric treatments should be differentiated not only in accordance with symptom expression but also in terms of personality traits, where some patients may need more support in their social context. ©2013 Nova Science Publishers, Inc. All rights reserved.