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Título del libro: Dopamine: Functions, Regulation And Health Effects
Título del capítulo: Dopamine and pain modulation in the insular cortex

Autores UNAM:
FRANCISCO JULIO PELLICER GRAHAM;
Autores externos:

Idioma:
Inglés
Año de publicación:
2012
Resumen:

The insular cortex was first described by the German anatomist Johann Christian Reil in the 18th century. Its discovery was immortalized by Henry Gray in the first edition of his famous book Gray's Anatomy (Binder et al., 2007). In spite of the considerable amount of time since its first description, the insular cortex has not been studied extensively due in part to its deep anatomical localization. However, recent clinical studies that have used techniques such as cerebral mapping as well as physiological and pharmacological studies in animals have helped studying in greater extent the functional neuroanatomy of the insular cortex. These have allowed to identify and describe its role in diverse functions such as memory, visceral sensory motor processes, sympathetic control of cardiovascular tone, as well as motor, gustatory, auditory, vestibular and emotional processes, added to cognition, pain and more recently, addiction (Augustine, 1996; Hanamori et al., 1998b; a). This multiplicity of functions involves several neurotransmission systems that converge in the insular cortex. Systems like the gabaergic, opiodergic, glutamatergic, serotoninergic and importantly, the dopaminergic have been described. This chapter focuses in functions related to the dopaminergic system in the insular cortex, especially those concerning the progress made in the field of pain research. © 2012 Nova Science Publishers, Inc.


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