Título del libro: Liver Cirrhosis: Causes, Diagnosis And Treatment
Título del capítulo: Role of the energy state of liver cell in cirrhosis development and treatment
FRANCISCO HERNANDEZ LUIS; MAURICIO DIAZ MUÑOZ;
Autores externos:
Idioma:
Inglés
Año de publicación:
2011
Resumen:
Cirrhosis is one of the most common causes of mortality worldwide because hepatic dysfunction constitutes a potentially lethal condition. Its etiology is variable being the most important alcoholic liver disease, viral chronic hepatitis and there's no treatment for prevention or regression of this pathology. At the same time, there is an increased risk of sepsis, bacterial peritonitis, variceal bleeding, portal hypertension and development of hepatocelular carcinoma. In this chapter, we briefly describe the normal structure and function of the liver including the importance of energy participation, in the normal and cirrhotic liver. Among the liver dysfunctions of this pathology exists a decrease in energy parameters in the blood of alcoholic and nonalcoholic patients with cirrhosis. In experimental cirrhosis induced with CCl4, a strong correlation between energy parameters of the liver and the red blood cells indicated that blood parameters could be a reflection of liver damage. Our experience regarding the studies of acute and chronic experimental hepatotoxicity using the nucleoside adenosine as an hepatoprotector suggest that the nucleoside effect increasing energy availability by itself, played and important role preventing the mitochondrial dysfunction induced by the hepatotoxics like ethanol, CCl4 in acute an chronic models. Regardless of the mechanism involved in the effects of adenosine on CCl4-induced cirrhosis in rats, the maintenance of the energy parameters of the liver cell during a chronic insult could be relevant to preserve liver function and the delay the fibrogenic effect of the toxin. More interesting is the beneficial effect of adenosine and adenosine derivative compound IFC305 on the preestablished CCl4 cirrhosis associated with an improved liver function. In summary, adenosine and its derivative, through reversed cirrhosis, liver dysfunction and energy parameters of the liver cells could be considered as a tool to study the interrelationship between mitochondrial function and hepatotoxicity. Besides, it could be considered as a potential therapeutic agent for the treatment of chronic hepatic diseases. ©2011 Nova Science Publishers, Inc. All rights reserved.
Entidades citadas de la UNAM:
ISBN:
9781612092485
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
Role of the energy state of liver cell in cirrhosis development and treatment
Página inicial:
31
Página final:
58
Tipo de producto:
Capítulo de un Libro
