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Título del libro: New Approaches In The Treatment Of Cancer
Título del capítulo: Metals in cancer treatment

Autores UNAM:
MARIA ELENA BRAVO GOMEZ; LENA RUIZ AZUARA;
Autores externos:

Idioma:
Inglés
Año de publicación:
2011
Resumen:

Bioinorganic chemistry offers many opportunities for medicinal chemistry research and the development of effective metal based chemotherapeutic agents. Metals have a large variety of coordination numbers and geometries, accessible redox states in physiological conditions and a wide range of thermodynamic and reactivity properties which can be successfully tuned by selection of suitable ligands. These characteristics can be used to develop new drugs with numerous advantages over the organic based drugs. Historically, research in this field has focus on platinum and DNA targeting; however, anticancer drug research may be expanded to include alternative metal compounds with different mode of action resulting in markedly different cytotoxic response profiles. The examples provided in this chapter were selected by the authors only to highlight some creative work in the field of anticancer metal based agents. The information about anticancer metal based drugs is organized in three main sections: platinum compounds, non platinum anticancer agents and essential metal based antitumor drugs. The latter section emphasizes the research on copper based agents Casiopeínas. © 2011 Nova Science Publishers, Inc. All rights reserved.


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