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Título del libro: Handbook Of Oxytocin Research: Synthesis, Storage And Release, Actions And Drug Forms
Título del capítulo: Oxytocin and classical transmitter release in the olfactory bulb during vaginocervical stimulation enhances social recognition memory

Autores UNAM:
ROSALINDA GUEVARA GUZMAN; OCTAVIO FABIAN MERCADO GOMEZ; VIRGINIA SELENE ARRIAGA AVILA;
Autores externos:

Idioma:
Inglés
Año de publicación:
2009
Palabras clave:

Memory; Olfactory system; Vagus nerve; Vcs


Resumen:

Oxytocin (OT) is one of the many centrally released neuropeptides that modulates social and reproductive behaviors. In the present chapter, we analyzed the release of OT and classical neurotransmitters in the olfactory bulb (OB) after vaginocervical stimulation (VCS) in the context of a social recognition memory test. The test was based upon comparison of investigation times between two encounters of an adult female rat and a conspecific juvenile separated by an interexposure interval of 30 or 300 minutes. Results showed that an intact social recognition memory was present at 30 min in animals with or without VCS at all stages of the estrus cycle. Only animals in proestrus/estrus that received VCS showed retention of the specific recognition memory at 300 min. Animals in all other stages of the cycle failed to retain the social recognition memory. Microdialysis studies demonstrated that noradrenaline, dopamine, aspartate, glutamate, GABA, arginine, citruline and oxytocin were released during VCS in the olfactory bulb and an increase of immunoreactive oxytocin fibers were also found. Administration of an oxytocin antagonist blocked the retention of the social recognition memory at 300 min in proestrus/estrus animals. Animals with vagus or pelvic nerve section did not show VCS-induced release of neurotransmitters in the olfactory bulb or memory retention when tested after 300 min in the social recognition test. These results demonstrate that oxytocin release in response to VCS may be responsible for improving the retention of social recognition memory in female rats.


Entidades citadas de la UNAM: