Título del libro: Pharmacoresistance In Epilepsy: From Genes And Molecules To Promising Therapies
Título del capítulo: Contribution of the antiepileptic drug administration regime in the development and/or establishment of pharmacoresistant epilepsy
LUISA LILIA ROCHA ARRIETA; SANDRA ADELA OROZCO SUAREZ;
Autores externos:
Idioma:
Inglés
Año de publicación:
2013
Palabras clave:
Arteriovenous drug plasma concentration ratio; Efflux transporters; Inducer drugs; Nonlinear response; Pharmacokinetics; Phenytoin; Refractory epilepsy; Salivary drug monitoring
Resumen:
Overexpression of membrane transporters is one of the main pharmacokinetic reasons that lead to the lack of response of antiepileptics in drug refractory treatments. The present chapter deals with the difficulty anticonvulsant agents have in reaching the brain receptor sites. An inducer and substrate of efflux transporter drug, when it is continuously administered so as to maintain constant levels in body fluids could become noneffective throughout time, even it was especially effective for a certain type of epilepsy. In spite of the fact phenytoin (PHT) is a well-known effective antiepileptic drug with characteristic nonlinear pharmacokinetics; resistance could be developed in epileptic patients during chronic treatments. Some new approaches that challenge conventional assumptions about its peculiar pharmacokinetics were consistent with the mechanism involved in refractory epilepsy. Salivary drug monitoring was a useful tool for understanding the mechanism of both pharmacokinetics and pharmacoresistance developed by PHT as inducer and substrate of efflux transporters. © 2013 Springer Science+Business Media, LLC. All rights are reserved.
Entidades citadas de la UNAM:
ISBN:
9781461464648
Editorial:
Springer New York Nombre de la publicación:
Contribution of the antiepileptic drug administration regime in the development and/or establishment of pharmacoresistant epilepsy
Página inicial:
169
Página final:
184
