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Título del libro: Pharmacoresistance In Epilepsy: From Genes And Molecules To Promising Therapies
Título del capítulo: Experimental models to study pharmacoresistance in epilepsy

Autores UNAM:
LUISA LILIA ROCHA ARRIETA;
Autores externos:

Idioma:
Inglés
Año de publicación:
2013
Palabras clave:

Antiepileptic drugs; Drug efflux transporters; Drug-resistant epilepsy; Human brain tissue; In vitro models; In vivo models; P-glycoprotein; Pharmacoresistance


Resumen:

At present, there are several experimental models focused on investigating the mechanisms underlying pharmacoresistance in epilepsy. The present chapter aims to briefly describe different experimental models suitable to investigate the mechanisms associated with drug-resistant epilepsy. The in vitro models are useful to evaluate some molecular mechanisms of resistance to antiepileptic drugs, whereas in vivo models allow the identification of animals that are responsive and nonresponsive to pharmacological therapy and detailing of factors associated to these responses. Finally, evaluation of tissue obtained from patients with pharmacoresistant epilepsy submitted to surgery can also be considered as a good strategy to identify the mechanisms related to this neurological disorder and confirm the results obtained from experimental models. © 2013 Springer Science+Business Media, LLC. All rights are reserved.


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