Título del libro: Pharmacoresistance In Epilepsy: From Genes And Molecules To Promising Therapies
Título del capítulo: Pharmacoresistant epilepsy and immune system
LUISA LILIA ROCHA ARRIETA; SANDRA ADELA OROZCO SUAREZ;
Autores externos:
Idioma:
Inglés
Año de publicación:
2013
Palabras clave:
Cytokine; Immune system; Inflammation; Pharmacoresistance; Temporal lobe epilepsy
Resumen:
The concept that the immune system plays a role in the epileptogenic process of some epileptic syndromes was first proposed more than 20 years ago. Numerous studies have reported the existence of a variety of immunological alterations in epileptic patients, favorable responses of refractory epilepsy syndromes to immune modulator treatment and the association of certain immune-mediated disease states with epilepsy. All common contributing factors to epilepsy such as trauma, malignancies, and infections are accompanied by different levels of central nervous system (CNS) inflammation, which, in turn, have been associated with the occurrence of seizures. In this chapter we provide an overview of the current knowledge on the relationship between the immune system and epilepsy. Recent knowledge suggesting the involvement of specific inflammatory pathways in the pathogenesis of seizures in patients with pharmacoresistant temporal lobe epilepsy (TLE) highlights the potential for new therapeutic strategies. We describe experimental and clinical evidences of immunological dysfunctions with special emphasis on clinical aspects, once the epileptogenic focus is resected. Further insight into the complex role of cellular immunity and inflammation in epileptogenesis should lead to new treatment options. © 2013 Springer Science+Business Media, LLC. All rights are reserved.
Entidades citadas de la UNAM:
ISBN:
9781461464648
Editorial:
Springer New York Nombre de la publicación:
Pharmacoresistant epilepsy and immune system
Página inicial:
149
Página final:
168
