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Título del libro: Cancer Immunology: A Translational Medicine Context
Título del capítulo: The role of exhaustion in tumorinduced t cell dysfunction in cancer

Autores UNAM:
HERIBERTO PRADO GARCIA; JOSE SULIVAN LOPEZ GONZALEZ;
Autores externos:

Idioma:
Inglés
Año de publicación:
2015
Resumen:

T cells are essential components of the immune system and have been the major focus of immunotherapeutic strategies to boost endogenous antitumor immunity. However, despite homing into tumor sites, infiltrating T cells seldom control tumor growth and T cell-directed immunotherapy has not been successful. Initially, anergy was implicated in the nonresponsiveness of T cells to tumors. Nevertheless, cancer has been hypothesized to be a chronic disease, in a similar fashion to chronic viral infections, where T cells are chronically stimulated. In this scenario, tumor-specific T cells become dysfunctional, progressively losing effector functions, such as cytolysis or cytokine secretion, a phenomenon known as T cell exhaustion. In this chapter, we will review the concept of T cell exhaustion; the mechanisms involved; the markers employed for the identification of exhausted T cells; the evidence for cancer-induced exhaustion, in particular in lung cancer; and the implications of this phenomenon on tumor immunology. © Springer-Verlag Berlin Heidelberg 2015.


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