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Título del libro: Recent Hispanic Psychological Research On Feeding Behavior And Hiv Patients
Título del capítulo: A 5-HT1A antagonist may enhance the anorectic effect of A 5-HT2C receptor agonist

Autores UNAM:
DAVID NATANAEL VELAZQUEZ MARTINEZ;
Autores externos:

Idioma:
Inglés
Año de publicación:
2014
Palabras clave:

Food Intake; Indorenate; Mesulergide; Methiothepin; Mianserin; Rats


Resumen:

Direct or indirect stimulation of serotonin receptors (5-HT2CR), 5-HTIBR and 5-HT6R subtypes decrease food intake while stimulation of 5-HT1AR increases it. Using non- selective drugs or increasing 5-HT at the synaptic cleft may bind to different subtypes producing opposing effects on intake, if this would be the case, agonist action at 5-HT1AR may obscure the anorectic effect. We tested the hypothesis that indorenate (INDO) an agonist with low affinity for 5-HT1B/2CRs that decreases food intake, but also with high affinity for 5-HT1AR, may benefit from the blockade of 5-HT1AR to clearly express its anorectic action. Male Wistar rats were trained to eat their food and water daily in a period of 4 h. On test days mesulergide (non-selective 5-HT2C/2A antagonist, 1.0 mg/kg), mianserin (non-selective 5-HT2A/2B/2C antagonist, 3.0 mg/kg), methiothepin (non-selective 5- HT1E/1F/1A antagonist, 0.3 mg/kg) or saline were given before INDO (17.0 mg/kg); a control group received two injections of saline. INDO decreased food intake; mesulergide and mianserin prevented its anorectic effect, although only the antagonism of mesulergide reached statistical significance. Methiothepin enhanced the anorectic effect of INDO. Blockade of 5-HT1AR allowed the observation of the full participation of the 5-HT2CR on the anorectic action of INDO. © 2014 by Nova Science Publishers, Inc. All rights reserved.


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