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Título del libro: Diazepam: Medical Uses, Pharmacology And Health Effects
Título del capítulo: Diazepam: Principal indications related with its molecular actions and advantages hugo juárez olguín, david calderón guzmán, ernestina hernández garcía and gerardo barragán mejía

Autores UNAM:
MATEO HUGO JUAREZ OLGUIN; ERNESTINA HERNANDEZ GARCIA;
Autores externos:

Idioma:
Inglés
Año de publicación:
2014
Resumen:

Diazepam is a long-acting classical benzodiazepine. The anticonvulsant properties of this and other benzodiazepines may be in part or entirely due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Diazepam is highly lipid-soluble, is widely distributed throughout the body after administration, and easily crosses the blood-brain barrier. It increases the central depressive effects of alcohol, other hypnotics/sedatives, narcotics, other muscle relaxants, certain antidepressants, sedative antihistamines, opiates, and antipsychotics, as well as anticonvulsants such as phenobarbital, phenytoin and carbamazepine. Although not usually fatal when taken alone, a diazepam overdose is considered a medical emergency and generally requires the immediate attention of medical personnel. The antidote for an overdose of diazepam or any other benzodiazepine is flumazenil. This drug is only used in cases of severe respiratory depression or cardiovascular complications. Indeed, improper or excessive use of diazepam can lead to psychological dependence/drug addiction. This paper reviews the possible mechanisms of diazepam and some benzodiazepines involved in oxidative stress and usual clinical therapy. Finally, common analytical techniques and biochemical markers used to monitor diazepam and common benzodiazepines in the same clinical therapy are also described in this recompilation. © 2014 by Nova Science Publishers, Inc. All rights reserved.


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