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Título del libro: Monkeys: Brain Development, Social & Hormonal Mechanisms And Zoonotic Diseases
Título del capítulo: The use of non-human primates as bio-models for aging brain studies: Interventional role of oxidative stress in demyelization processes

Autores UNAM:
HECTOR ADRIAN POBLANO LUNA; FELIX EDUARDO TENA BETANCOURT;
Autores externos:

Idioma:
Inglés
Año de publicación:
2014
Palabras clave:

Aging; Demyelinization; Non-human primate; Oxidative stress


Resumen:

Aging has been characterized as a functional decline that impairs an array of physiological functions. It has been stated that many changes that take place at a molecular level during brain aging and neurodegenerative diseases (ND), operate through a common underlying mechanism which has been associated to an oxidative damage to macromolecules. This situation is enhanced by an oxidative homeostatic imbalance which occurs through an increase in reactive oxygen and nitrogen species production, accompanied by a decline in antioxidant systems, thus leading to oxidative damage accumulation. The nervous system (NS) has a high oxidative metabolism being therefore more vulnerable to oxidative injury. Hence, it is important to develop and apply sever diagnostic tools and biomodels, in order to characterize early and progressive stages of ND, and differentiate them from mild-stable alterations of normal aging wear and tear process. As a result, the use of evoked potentials (EP's) has proved to be a reliable diagnostic indicator, with high sensitivity and specificity to evaluate sensory pathways. The non-human primates (NHP) have been widely used as biomodels for brain aging studies and ND, providing information related to the physiological changes associated to age in non-pathological conditions, hence differentiating them from true pathological processes that occur during ND. © 2014 by Nova Science Publishers, Inc. All rights reserved.


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