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Título del libro: Mifepristone: Pharmacology, Medical Uses And Potential Side Effects
Título del capítulo: Mifepristone blocks progesterone-induced cell proliferation and migration in human astrocytoma cells

Autores UNAM:
ALIESHA ARACELI GONZALEZ ARENAS; VALERIA HANSBERG PASTOR; IGNACIO CAMACHO ARROYO;
Autores externos:

Idioma:
Inglés
Año de publicación:
2014
Resumen:

Progesterone (P4) promotes cell proliferation in several types of cancer, including brain tumors such as astrocytomas, which are the most common and aggressive primary intracerebral neoplasms in humans. P4 exerts many of its effects through the interaction with its intracellular receptor (PR), a ligand-activated transcription factor involved in the regulation of genes related to the proliferation and migration of cancer cells. PR expression directly correlates with astrocytomas grade, suggesting that PR-positive tumors exhibit a high proliferative potential. It has been reported that P4 induces proliferation of U373 and D54 cell lines, which are derived from human astrocytomas grades III and IV (glioblastoma), respectively, and that the administration of the PR antagonist mifepristone, blocks P4 effects. Interestingly, the treatment with mifepristone alone significantly reduces astrocytoma cells proliferation in vitro. We have demonstrated that P4 promotes the growth and infiltration of U373 cells implanted in the cerebral motor cortex of the rat. Importantly, mifepristone also blocks these effects. Besides, it has been reported that mifepristone improves the efficacy of chemo-radiotherapy in glioblastoma xenografts in mice. All these data indicate that mifepristone has important effects over human astrocytomas growth and strongly suggest its use as a putative alternative for the treatment of this type of tumors. © 2014 Nova Science Publishers, Inc.


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