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Título del libro: Pituitary Today Ii: New Molecular, Physiological And Clinical Aspects
Título del capítulo: Vasoinhibins and the Pituitary Gland

Autores UNAM:
ISABEL CRISTINA MENDEZ HERNANDEZ; GONZALO MARTINEZ DE LA ESCALERA LORENZO; MARIA DEL CARMEN CLAPP JIMENEZ L.; BIBIANA MORENO CARRANZA;
Autores externos:

Idioma:
Inglés
Año de publicación:
2010
Resumen:

Vasoinhibins are a family of peptides that inhibit blood vessel growth, dilation, permeability, and survival. They are generated by the proteolytic cleavage of prolactin by cathepsin D, matrix metalloproteases, and bone morphogenic protein-1. Lactotropes within the anterior pituitary gland produce and release vasoinhibins. Hypothalamic neurons within the supraoptic and paraventricular nuclei also synthesize prolactin and process it to vasoinhibins that are released locally or at the neurohypophyseal endings. While both the anterior and posterior pituitaries may function as sources of circulating vasoinhibins, these peptides could act as local regulators of pituitary gland functions including neovascularization and neurohypophyseal hormone release. Copyright (C) 2010 S. Karger AG, Basel


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