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Título del libro: Essays In Biochemistry: Chronobiology
Título del capítulo: Mammalian clock output mechanisms

Autores UNAM:
RUDOLF MARINUS BUIJS;
Autores externos:

Idioma:
Inglés
Año de publicación:
2011
Resumen:

In mammals many behaviours (e.g. sleep wake, feeding) as well as physiological (e.g. body temperature, blood pressure) and endocrine (e.g. plasma corticosterone concentration) events display a 24 h rhythmicity. These 24 h rhythms are induced by a timing system that is composed of central and peripheral clocks. The highly co-ordinated output of the hypothalamic biological clock not only controls the daily rhythm in sleep wake (or feeding fasting) behaviour, but also exerts a direct control over many aspects of hormone release and energy metabolism. First, we present the anatomical connections used by the mammalian biological clock to enforce its endogenous rhythmicity on the rest of the body, especially the neuro-endocrine and energy homoeostatic systems. Subsequently, we review a number of physiological experiments investigating the functional significance of this neuro-anatomical substrate. Together, this overview of experimental data reveals a highly specialized organization of conne


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