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Título del libro: International Review Of Cell And Molecular Biology, Vol 293
Título del capítulo: NEW INSIGHTS INTO THE REGULATION OF MYOSIN LIGHT CHAIN PHOSPHORYLATION IN RETINAL PIGMENT EPITHELIAL CELLS

Autores UNAM:
ANA MARIA LOPEZ COLOME;
Autores externos:

Idioma:
Inglés
Año de publicación:
2012
Palabras clave:

Retinal pigment epithelium; Actin cytoskeleton; Non-muscle myosin II; MLC phosphorylation; Cell contraction


Resumen:

The retinal pigment epithelium (RPE) plays an essential role in the function of the neural retina and the maintenance of vision. Most of the functions displayed by RPE require a dynamic organization of the acto-myosin cytoskeleton. Myosin II, a main cytoskeletal component in muscle and non-muscle cells, is directly involved in force generation required for organelle movement, selective molecule transport within cell compartments, exocytosis, endocytosis, phagocytosis, and cell division, among others. Contractile processes are triggered by the phosphorylation of myosin II light chains (MLCs), which promotes actin myosin interaction and the assembly of contractile fibers. Considerable evidence indicates that non-muscle myosin II activation is critically involved in various pathological states, increasing the interest in studying the signaling pathways controlling MLC phosphorylation. Particularly, recent findings suggest a role for non-muscle myosin II-induced contraction in RPE cell tra


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