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Título del libro: Epigenetic Gene Expression And Regulation
Título del capítulo: Long noncoding RNAs and carcinogenesis

Autores UNAM:
FELIX RECILLAS TARGA;
Autores externos:

Idioma:
Inglés
Año de publicación:
2016
Palabras clave:

TUMOR-SUPPRESSOR GENE; MUSCLE DIFFERENTIATION; COLORECTAL-CANCER; NUCLEAR-RNA; HEPATOCELLULAR-CARCINOMA; CLINICAL-SIGNIFICANCE; PROSTATE-CANCER; ANTISENSE RNA; SELF-RENEWAL; PAR-CLIP


Resumen:

A large portion of the human genome is transcribed into noncoding RNA molecules with many different forms and accomplishing a remarkable variety of functions. Those functions are frequently associated to the recruitment and targeting of chromatin-remodeling complexes to specific set of genes. However, activities such as RNA processing and translation are also regulated by noncoding RNAs. The great variety of possibilities associated to RNA-protein interactions lead one to propose that the regulatory effect of noncoding RNA can be, in normal and pathological conditions, visualized as an amplifier signal with multiple genomic targets and effects, which are restricted to specific cell lineages. This chapter describes the general features of long noncoding RNAs, some examples of their varied functions, and their role in distinct human diseases, including cancer. © 2015 Elsevier Inc.


Entidades citadas de la UNAM: