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Título del libro: Biomedical Engineering And Informatics: New Development And The Future - Proceedings Of The 1st International Conference On Biomedical Engineering And Informatics, Bmei 2008
Título del capítulo: Genome regions involved in multiple regulatory pathways identified using GSEL, a genome-wide database of regulatory sequence elements of geobacter sulfurreducens

Autores UNAM:
CINTHIA ERNESTINA NUÑEZ LOPEZ;
Autores externos:

Idioma:

Año de publicación:
2008
Palabras clave:

Biomedical engineering; Biophysics; Bioremediation; Computer networks; Database systems; Forecasting; Gene expression; Informatics; International conferences; Transcription


Resumen:

Organisms from the metal-reducing family Geobacteraceae participate in bioremediation of contaminated environments and in energy harvesting. We have developed a database and an accompanying online query system, GSEL, for Geobacter Sequence Elements (available from http://www.geobacter.org/research/ gsel/). It compiles information on predicted transcription regulatory elements in the genome of G. sulfurreducens. These elements were derived from analyses that employed genome-wide transcription profiling, comparative genomics, and similarity searches. Clustering was employed to group overlapping sequence elements with similar genome locations. Subsequent scoring and sorting allowed us to identify individual sequence elements and regulatory clusters that were predicted by the highest number of independent microarray gene expression and sequence comparison data sets. These sequence elements and genome regions are likely to be involved in gene regulation under a variety of conditions or in multiple biological pathways. © 2008 IEEE.


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