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Título del libro: Technical Proceedings Of The 2011 Nsti Nanotechnology Conference And Expo, Nsti-Nanotech 2011
Título del capítulo: Nanosized titania reservoirs for epilepsy treatment

Autores UNAM:
ANNA KOZINA;
Autores externos:

Idioma:

Año de publicación:
2011
Palabras clave:

Drug release; Drug-matrix interactions; Epilepsy; Phenytoin; Titania


Resumen:

We carried out elaborate studies on phenytoin encapsulation within the titania matrix. We changed the parameters of the sol-gel synthesis to play with the drug-matrix interactions and titania morphology to design the release kinetics. First, we showed that hydroxyl groups of titania matrix are the main interaction sites with hydantoin ring of phenytoin. We confirmed that there may be two possible complexes formed between the drug and the matrix, where one or two hydroxyl groups participate. The probability of each complex depends on the hydroxyl group coverage of the titania surface, which, in its turn, depends on the water/alkoxide ratio used in the sol-gel synthesis. Second, we varied the water/alkoxide ratio to investigate how this would affect the morphology of the matrix and, as a result, the drug release kinetics. Finally, we applied characterization techniques to study the morphology of the matrix to explain the release 'in vitro'.


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