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SIIA Público
SISTEMA INTEGRAL DE INFORMACIÓN ACADÉMICA - PÚBLICO
Título del libro: Biocompatibility Of Liposomes Derived From Microbial Cells: An Assesment Towards Nanomedicine Applications
The emergence of Nanotechnology in Medicine has resulted in the
development of a wide set of nanocarriers. One of the most popular
approaches in drug delivery is the use of liposomes, which are
self-assembled lipid bilayers. Mammalian-derived liposomes are known to
be highly biocompatible. However, the toxicity of liposomes prepared
with microbial lipids is still to be clarified. Strains from the genus
Mycobacterium are able to induce a high immune response in humans, which
is known to involve the responses towards the amphipathic lipids they
synthesize, and various reports have proposed the use of mycobacterial
liposomes as adjuvants and vaccine boosts. In this work, M. fortuitum
and M. tuberculosis lipids were used to produce mycobacterial-derived
liposomes, and their physical and chemical characterization, as well as
biocompatibility vis-a-vis human cells are addressed.
Entidades citadas de la UNAM:
Fuente:
ISBN: 9781509029112 Editorial: Institute of Electrical and Electronics Engineers Inc.