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Título del libro: Evolution Of Trnas Was Driven By Entropic Forces
Título del capítulo: The diversification of eIF4E family members in plants and their role in the plant-virus interaction

Autores UNAM:
TZVETANKA DIMITROVA DINKOVA; LEON PATRICIO MARTINEZ CASTILLA;
Autores externos:

Idioma:
Inglés
Año de publicación:
2016
Palabras clave:

Algae; Machinery; Proteins; Seed; Translation (languages); Cellular function; Cellular process; Direct interactions; eIF4E; Natural selection; Potyviruses; Recent researches; Regulatory mechanism; Viruses


Resumen:

Recruitment of eukaryotic mRNAs by the translation machinery requires binding of their 5? end (cap) to eIF4E in complex with the bridge protein eIF4G (eIF4F). Plant eIF(iso)4E and eIF(iso)4G form the eIF(iso)4F complex, distinct from eIF4F (formed by eIF4E and eIF4G). Separate eIF(iso)4E and eIF4E clades are detected upon seed plants? arrival in evolution, while eIF(iso)4G has been present since green algae. Strong preference is observed between eIF(iso)4G and eIF(iso)4E, as well as between eIF4E and eIF4G in vitro and in vivo, suggesting that these complexes exert functionally distinct roles in seed plants. However, the regulatory mechanisms underlying their role in translation or other cellular processes remain mainly unknown, with the notable exception of plant-virus interaction. Individual isoforms are required in a specific way for successful virus infection in a range of plant species. The isolation of resistance-associated mutations in eIF4E family members pinpointed their role through direct interaction with the viral genome-linked protein VPg. In this chapter we review recent research on eIF4E diversification with emphasis on their cellular function and roles in the specificity of plant-virus interaction. © Springer International Publishing Switzerland 2016. All rights reserved.


Entidades citadas de la UNAM: