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Título del libro: Astrovirus Replication And Reverse Genetics

Autores UNAM:
CARLOS FEDERICO ARIAS ORTIZ; TOMAS DAVID LOPEZ DIAZ;
Autores externos:

Idioma:
Inglés
Año de publicación:
2016
Palabras clave:

TERMINAL NSP1A PROTEIN; NONSTRUCTURAL PROTEINS; CRYSTAL-STRUCTURE; CACO-2 CELLS; RNA SEQUENCE; CAPSID SPIKE; CDNA-CLONE; VIRUS; INFECTION; IDENTIFICATION


Resumen:

Astroviruses are significant causes of gastroenteritis in both humans and animals, and are also associated to extraintestinal infections, including neurological disease in mammals and hepatitis and nephritis in birds. Herein we summarize our current knowledge on the different stages of the replication cycle of astroviruses, most of which is derived from the characterization of classical human astroviruses (serotypes 1-8) in Caco-2 cells. We also describe the reverse genetic system that has been developed for human astrovirus serotype 1 and the potential it has to improve our understanding of the virus lifecycle, to define virulence determinants, and eventually to develop safe vaccine candidates. © 2016 Elsevier Inc. All rights reserved.


Entidades citadas de la UNAM: