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Título del libro: Tau Proteins

Autores UNAM:
JOSE FERNANDO PEÑA ORTEGA;

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Autores externos:

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Idioma:
Inglés

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Año de publicación:
2016

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Palabras clave:

Amyloid beta; Cocktail therapies; Dystrophic neurites; Phosphorylation; Synaptic failure; Synaptic plasticity; Tau

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Resumen:

Alzheimer's disease (AD) is classically defined by the accumulation of abnormal aggregates mainly comprised of two proteins: phosphorylated tau (ptau) and amyloid beta (Aß). It has been proposed that those aggregates lead to several cellular changes that are translated into neuronal loss and the impoverishment of cognitive functions. Although there is a strong correlation between these protein aggregates and dementia, the exact mechanisms connecting their pathological effects remain poorly understood. Indeed, the role of Aß deposition as the event that causes the AD pathology is currently under heated debate. In contrast, tau deposits are far more related to clinical dementia. However, during AD development, the dynamic cellular and molecular relationship between tau and Aß remains under extensive study. Clearly, both proteins are well related to the disease progression and not surprisingly both are currently the main therapeutic targets for new AD treatments. Unfortunately, nothing but moderate success has emerged from a variety of therapeutic strategies targeting either tau or Aß. One potential explanation for the current failure is that therapeutic interventions are provided at late stages of the disease instead of being administrated at early stages. Taking this hypothesis into account, we will discuss the role of abnormally ptau protein as an early AD marker and discuss the molecular relationships between Aß and ptau during synaptic activity. Finally, as a proposal that aims to restore normal brain activity, we will briefly discuss a therapeutic strategy that would be based on modifying several tau protein targets by cocktail therapies. © 2017 Elsevier Inc. All rights reserved.

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Entidades citadas de la UNAM:

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Fuente:



ISBN:
9780128028117
Editorial:
Elsevier Inc. Nombre de la publicación:
Tau Proteins
Página inicial:
145
Página final:
160

Tipo de producto:
Capítulo de un Libro

DOI:
10.1016/B978-0-12-802810-0.00008-8