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Título del libro: Plga And Plga-Peg Nanoparticles Loaded With Curcumin And Their Effect On Aflatoxin B1 In Vitro

Autores UNAM:
ROBERTO DIAZ TORRES; PATRICIA RAMIREZ NOGUERA;
Autores externos:

Idioma:
Inglés
Año de publicación:
2015
Palabras clave:

Aflatoxins; Oxidative stress; Toxicity; Curcumin; GSH concentrations; Human hepatocytes; Lipid peroxidation; Oxidative DNA damage; PLGA; Plga pegs; Poly lactic-co-glycolic acid; Nanoparticles


Resumen:

Aflatoxin B1 (AfBl) is a potent hepatotoxic and hepatocarcinogenic mycotoxin. Lipid peroxidation and oxidative DNA damage are the main manifestations of toxicity induced by aflatoxin B1 that could be counteracted by antioxidants. The aim of this study was to evaluate the effect of nanoparticles prepared with polylactic-co-glycolic acid (PLGA) and PLGA with polyethylene glycol (PLGA- PEG) loaded with curcumin in human hepatocytes exposed to aflatoxin B1 in vitro. Some biomarkers associated to oxidative stress were estimated. The results showed an increase in GSH concentration in cells exposed to nanoparticles with curcumin. PLGA-PEG nanoparticles showed more significant difference compared to control. These results suggest that curcumin loaded nanoparticles can modulate cellular effects associated with oxidative stress in vitro. Copyright 2015 by TechConnect. All rights reserved.


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