Título del libro: Optimization Of Drug Prescribing In Elderly
Título del capítulo: Different methods used to determine the pharmacokinetics parameters
JUAN LUIS CHAVEZ PACHECO; MATEO HUGO JUAREZ OLGUIN;
Autores externos:
Idioma:
Inglés
Año de publicación:
2016
Resumen:
The correct interpretation of what happens to a drug in the body after its administration, intra or extravascular route, resides on its movement with in the organism. This movement is known by information obtained from the pharmacokinetics profile of the drug expressed in terms of velocity. Hence, pharmacokinetics is defined as ?the transformations a drug undergoes after its entrance into the organism,? The pharmaco-kinetic parameters can only be obtained by means of mathematical models. However, there are various methods or models to calculate the pharmacokinetic parameters of a drug. In the first place, it is important to consider the organism as a compartmental system with millions of compartments and then from a parsimonial point of view, find a simple mathematical model that would explain the pharmacokinetic processes from which we could derive mathematical equations that would define the pharmacokinetic parameters. Presently, there are two mathematical models the compartmental and non-compartmental. The compartmental model considers the velocity of entrance into, distribution in and egress of the drug from the organism, as well as the velocity of transference (or passage) from central compartment (more irrigated organs) to peripheral compartment (less irrigated organs) and vice versa. Fortunately in the present time, there are computer software which facilitate with high accuracy and speed the mathematical calculations to arrive at the pharmacokinetic parameters even if the data required to be adjusted to an open compartment model or to multi-compartment models an example of which may be the case of two-compartment open model. This chapter is intended to take the reader step by step into what happens to a drug starting from the moment in which its plasma concentrations are obtained in function of time to graph the results in which the relations of drug concentrations versus time is expressed. The later would permit the definition of the compartmental model that best adjusts to the experimental data. Once the compartmental model is defined, the pharmacokinetic parameters are obtained and their clinical interpretations are carried out. © 2016 Nova Science Publishers, Inc. All rights reserved.
Entidades citadas de la UNAM:
ISBN:
9781634848961
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
Different methods used to determine the pharmacokinetics parameters
Página inicial:
77
Página final:
99
Tipo de producto:
Capítulo de un Libro
