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Título del libro: Optimization Of Drug Prescribing In Elderly
Título del capítulo: Meaning of pharmacokinetic parameters

Autores UNAM:
MATEO HUGO JUAREZ OLGUIN;
Autores externos:

Idioma:
Inglés
Año de publicación:
2016
Resumen:

A pharmacokinetic parameter is an essential data, a variable or a factor to evaluate changes which certain situation or substance can undergo when subjected to certain condition. Drugs when administered undergoes a series of certain changes governed by a kinetic reaction process measured by their velocity to be liberated, absorbed, distributed, metabolized or excreted (LADME System). From each of these kinetic processes of velocity, a measurement of the functional capacity as well as the participating enzymatic system in each of the processes is obtained. The values gotten in these measurements are considered as markers of the functional capacities to eliminate a foreign body/substance as food, drugs, poison, environmental pollutants or any xenobiotic substance from the body. The obtained pharmacokinetic parameters corresponding to each of the kinetic process of absorption, distribution, metabolism and excretion are individual measurements unique for every person and every one of them is subject to intra and interindividual variability in line with the pharmacogenetics and biological processes as well as physical activities and environmental factors in which the person is exposed. This gives rise to the importance of individualization or personalization of a treatment regimen taking into account the characteristics of every patient. Presently, the establishment of a treatment regimen ought to be based on preventive pharmacogenetics diagnoses and optimization that are achieved from a pharmacokinetic knowledge of each patient and with orientation towards personalized pharmacotherapy. © 2016 Nova Science Publishers, Inc. All rights reserved.


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