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Título del libro: Nanostructures Based On Dna Origami And Applications

Autores UNAM:
ENRIQUE CUAUHTEMOC SAMANO TIRADO;

Autores externos:

Idioma:
Inglés

Año de publicación:
2016

Resumen:

The study of new materials having an engineering specific purpose involves the search of the relationship between synthesis, structure, properties and performance which depend on the materials and fabrication method. Lately, there has been an increasing focus on nanostructured materials inspired by nature, bioinspired or biomimetic. In particular, nanotechnology and biotechnology have merged with an entirely new set of inorganic, organic and biological building blocks to design and assemble nano-engineered materials with unique functionalities. The robust molecular recognition and programmability of DNA has inspired scientists to use DNA as a structural material since the seminal paper by N. Seeman [1]. The specificity of Watson-Crick complementary base pairing leads to intra- and intermolecular interactions which are predictable and programmable. As a result, a whole field of DNA nanotechnology has evolved and aimed at building increasingly complex nanostructures and introducing multiple functionalities. One of the major breakthroughs in DNA structural nanotechnology has been DNA origami technique, designed and demonstrated by P. Rothemund [2]. In this case, DNA can be manipulated into almost any nanostructure (size ~100 nm) with a predetermined shape by folding a long single-stranded scaffold DNA in the presence of complementary short single strands. One of the key goals of DNA nanotechnology is using the molecularly precise DNA 2D and 3D structures as templates to organize other materials. In the past few years DNA origami in particular has been used as a molecular pegboard to organize a variety of functional materials and to control the distance between them with nanometer precision. The ability to organize such a wide variety of objects opens the door to the creation of highly multifunctional nanostructures. Intricate materials with micron-scale dimensions and nanometer-scale feature resolution created via engineered DNA self-assembly are an important new class in nanotechnology. These assemblies are increasingly being employed as templates for the programmed assembly of functional inorganic materials, like metallic nanoparticles, that have not conventionally lent themselves to organization by molecular recognition processes. The current challenge is to apply these bioinspired DNA templates toward the fabrication of composite materials for use in electronics, photonics, diagnostic and therapeutic in human health, etc. Over the last three decades the understanding of how to fabricate complex and even active DNA nanostructures has increased dramatically, but further research needs to be pursued. While new techniques are still being developed, researchers are now also focusing on issues associated with applications. The proposed chapter will address the design and construction principles of nanostructures based on DNA origami, the precise binding of metallic nanoparticles at selected sites as an artificial biomineralization method. © 2017 Nova Science Publishers, Inc. All rights reserved.

Entidades citadas de la UNAM:

Fuente:

ISBN:
9781536103991
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
Nanostructures based on DNA origami and applications
Página inicial:
77
Página final:
101