ERROR:SQLSTATE[HY000]: General error: 20018 Invalid column name 'CodigoInstitucion'. [20018] (severity 16) [SELECT PublicObrasAutores.NumeroEmpleado, PublicObrasAutores.ApellidoPaterno, PublicObrasAutores.ApellidoMaterno, PublicObrasAutores.Nombre, PublicObrasAutores.NombreCompleto FROM PublicObrasAutores LEFT JOIN PublicObrasAutoresFil ON PublicObrasAutores.RefPublicacion = PublicObrasAutoresFil.RefPublicacion WHERE PublicObrasAutores.RefPublicacion = '455921' AND PublicObrasAutores.NumeroEmpleado IS NULL AND PublicObrasAutoresFil.CodigoInstitucion IS NOT NULL;]
®
ERROR:SQLSTATE[HY000]: General error: 20018 Invalid column name 'CodigoInstitucion'. [20018] (severity 16) [SELECT PublicObrasAutores.NumeroEmpleado, PublicObrasAutores.ApellidoPaterno, PublicObrasAutores.ApellidoMaterno, PublicObrasAutores.Nombre, PublicObrasAutores.NombreCompleto FROM PublicObrasAutores LEFT JOIN PublicObrasAutoresFil ON PublicObrasAutores.RefPublicacion = PublicObrasAutoresFil.RefPublicacion WHERE PublicObrasAutores.RefPublicacion = '455921' AND PublicObrasAutores.NumeroEmpleado IS NULL AND PublicObrasAutoresFil.CodigoInstitucion IS NULL;]
®
ERROR:SQLSTATE[HY000]: General error: 20018 Invalid column name 'Institucion'. [20018] (severity 16) [SELECT Institucion FROM PublicObrasAutoresFil WHERE RefPublicacion = '455921']
®
ERROR:SQLSTATE[HY000]: General error: 20018 Invalid column name 'Institucion'. [20018] (severity 16) [SELECT Institucion FROM PublicObrasAutoresFil WHERE RefPublicacion = 455921 AND InstitucionPropia = 'S'
UNION
SELECT Adscripciones.Entidad FROM PublicacionesObras
JOIN PublicObrasAutores ON PublicacionesObras.Identificador = PublicObrasAutores.RefPublicacion
JOIN Adscripciones ON PublicObrasAutores.NumeroEmpleado = Adscripciones.NumeroEmpleado
WHERE (PublicacionesObras.FechaPublicacion BETWEEN Adscripciones.FechaDesde AND Adscripciones.FechaHasta OR (PublicacionesObras.FechaPublicacion >= Adscripciones.FechaDesde AND Adscripciones.FechaHasta IS NULL)) AND PublicacionesObras.Identificador= 455921]
SIIA Público
SISTEMA INTEGRAL DE INFORMACIÓN ACADÉMICA - PÚBLICO
Título del libro: Update On Dementia Título del capítulo: Beta Amyloid Peptides: Extracellular and Intracellular Mechanisms of Clearance in Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disease and the most
common form of dementia, characterized by the overproduction and
accumulation of different amyloid-beta peptide peptides (A beta) within
different areas in the brain conducting to memory loss and dementia. The
A beta cascade hypothesis of AD was originally proposed by Selkoe in
1991 by the theory that accumulation of A beta 42 is the initial trigger
for neurodegeneration. The A beta cascade hypothesis assumes that
changes in the production or accumulation of A beta are responsible for
AD pathology. Different A beta clearance mechanisms are also affected by
AD pathology. Studies from the past years have revealed that the
blocking of A beta production is not effective for reducing the brain A
beta levels. However, the relevance of A beta clearance in AD,
especially in late-onset sporadic AD (LOAD), has been heightened, and
the study of the A beta clearance mechanisms has elucidated new possible
therapeutic targets. This chapter summarizes recent data underlying the
idea of the reduced A beta clearance and subsequent A beta spread in AD.
We discuss the A beta clearance mechanisms altered in AD, and the A beta
clearance through autophagy in more detail, a more recent mechanism
proposed, and the new strategies to eliminate A beta 42 inducing
autophagy.
