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SIIA Público
SISTEMA INTEGRAL DE INFORMACIÓN ACADÉMICA - PÚBLICO
Título del libro: Update On Dementia Título del capítulo: Diabetes Mellitus and Depression as Risk Factors for Dementia: SADEM Study
dementia; depression; diabetes mellitus; cognitive function; Mexican population
Resumen:
Aim: 3Evidence indicates that the comorbidity of dementia with diabetes
and depression may affect most cognitive functions. Our chief interest
was to examine the patterns of cognitive functioning in individuals
diagnosed with dementia, diabetes, and depression as compared with
dementia plus diabetes (DDM), or dementia plus depression (DD) and
healthy controls.
Methods: We included 207 participants with dementia (age 60+), 83 with
Alzheimer's disease (AD), 66 vascular dementia (VaD), and 58 mixed
dementia (AD/VaD). The Mini Mental State Examination (MMSE) was used for
global neuropsychological assessment, and the Center for Epidemiologic
Studies Depression Scale for symptoms of depression. Diabetes was
confirmed by medical diagnosis.
Results: Analysis showed differences in cognitive functioning among the
groups with statistical significance. Notably, there was greater
cognitive dysfunction in patients with diagnosis of dementia and
depression than in controls, but the difference was reduced in patients
with comorbid dementia diabetes. Subsequent comparisons indicated that
vascular dementia with comorbid depression and diabetes presents
significantly inferior cognitive performance than those with dementia
alone or the control group.
Conclusions: These results suggest that dementia, when combined with
depression or diabetes, adversely affects cognitive performance. These
findings highlight the importance of identifying depression among
diabetics and patients with dementia.