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Título del libro: Autonomic Innervation Of The Heart: Role Of Molecular Imaging
Título del capítulo: Imaging sympathetic innervation of the heart: Therapeutic strategies SPECT/CT and PET/CT

Autores UNAM:
ERICK ALEXANDERSON ROSAS;
Autores externos:
Idioma:
Inglés
Año de publicación:
2015
Palabras clave:

Amines; Diagnosis; Medical imaging; Neurophysiology; Norepinephrine; Patient treatment; Cardiac transplantation; Heart failure; Medical therapy; Presynaptic; Radiolabeling; Radionuclide imaging; SPECT/CT; Therapeutic strategy; Heart

Resumen:

Tracers for radionuclide imaging of cardiac neurotransmission have been developed by radiolabeling true neurotransmitters or corresponding structural analogs (false neurotransmitters). The most commonly used radiopharmaceuticals to assess cardiac neurotransmission are [11 C]-metahydroxyephedrine ([11 C]-mHED), [11 C]-ephedrine, [18 F]-dopamine, and [123 I]-metaiodobenzylguanidine ([123 I]-MIBG), which estimate neuronal presynaptic reuptake (type I uptake) and storage of norepinephrine (NE). In heart failure (HF), there is impairment of the neuronal uptake of NE in the myocardium due to chronic sympathetic activation. Reduced myocardial uptake of these radiotracers is an indicator of poor prognosis for HF patients. Cardiac adrenergic imaging might be useful as an indicator of whether or not the HF patient's medical therapy is effective and could therefore help determine whether higher-risk and usually more expensive device therapies or cardiac transplantation is needed. © Springer-Verlag Berlin Heidelberg 2015.

Entidades citadas de la UNAM:
Fuente:


ISBN:
9783662450741
Editorial:
Springer Berlin Heidelberg Nombre de la publicación:
Imaging sympathetic innervation of the heart: Therapeutic strategies SPECT/CT and PET/CT
Página inicial:
367
Página final:
385

Tipo de producto:
Capítulo de un Libro



DOI:
10.1007/978-3-662-45074-1_19