®®®® SIIA Público

Título del libro: Phagocytosis: Overview, History And Role In Human Health And Disease
Título del capítulo: How do microbial pathogens escape from phagocytosis?

Autores UNAM:
EILEEN URIBE QUEROL;
Autores externos:

Idioma:
Inglés
Año de publicación:
2018
Resumen:

Phagocytosis is a cellular process to capture and ingest particles larger than 0.5 µm. In pluricellular organisms, all cells can perform phagocytosis to some extent. But a group of specialized cells, called professional phagocytes, perform phagocytosis very efficiently. These phagocytes capture and destroy pathogenic microorganisms, and also eliminate apoptotic cells. The process of phagocytosis involves a series of steps including recognition of the particle, formation of a phagocytic vacuole (phagosome), maturation of this phagosome into a phagolysosome, and destruction of the ingested particle within the phagolysosome. Phagocytosis is usually an efficient process. However, several microbial pathogens possess multiple mechanisms to block phagocytosis at different levels. These pathogens have a clear advantage to perpetuate the infection and continue their replication. In this chapter, we present an outline of phagocytosis and then we describe the antiphagocytosis tactics of several important pathogens. Among these pathogens we find examples of microbial tactics to inhibit phagocytosis either at the level of ingestion, phagosome formation and maturation, and also escape from phagosomes. © 2018 Nova Science Publishers, Inc. All rights reserved.


Entidades citadas de la UNAM: