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Título del libro: Drug Treatment Of Sleep Disorders
Título del capítulo: Cell Therapy to Treat Narcolepsy

Autores UNAM:
OSCAR ARIAS CARRION;
Autores externos:

Idioma:

Año de publicación:
2015
Palabras clave:

OREXIN-A LEVELS; HYPOCRETIN OREXIN; LATERAL HYPOTHALAMUS; LOCUS-COERULEUS; NEURONS; SLEEP; RATS; AROUSAL; OREXIN/HYPOCRETIN; TRANSPLANTATION


Resumen:

The sleep disorder narcolepsy may now be considered a neurodegenerative disease, as there is a massive reduction in the number of neurons containing the neuropeptide, hypocretin/orexin (Hcrt). Hcrt neurons are solely located in the hypothalamus, particularly in its perifornical, dorsomedial, and lateral portions. Hcrt fibers widely project throughout the brain and generally have excitatory effects on their postsynaptic cells. Patients with narcolepsy have a severe reduction in the levels of Hcrt in the cerebrospinal fluid (CSF), a finding consistent with Hcrt neuronal loss. Experimental models have been generated in order to study the physiology of the Hcrt system and narcolepsy. In consequence, the Hcrt neuronal loss provokes depletion in CSF Hcrt levels and displays behavioral narcoleptic-like symptoms. Given that the Hcrt depletion is the hallmark of narcolepsy, these models represent the opportunity to explore the potential use of transplants as a therapeutical tool in order to treat narcolepsy.


Entidades citadas de la UNAM: