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Título del libro: 2017 14th International Conference On Electrical Engineering, Computing Science And Automatic Control, Cce 2017
Título del capítulo: Simulation and in vivo validation of craniotomies in rats for the disruption of the blood brain barrier with focused ultrasound for drug delivery

Autores UNAM:
DANIEL MARTINEZ FONG;
Autores externos:

Idioma:
Inglés
Año de publicación:
2017
Palabras clave:

Acoustic fields; Automation; Blood vessels; Process control; Rats; Ultrasonics; Acoustic field patterns; Blood-brain barrier; Central nervous systems; craniotomy; Field distortions; Focused ultrasound; Selective permeability; Transmission loss; Neurodegenerative diseases


Resumen:

The blood brain barrier (BBB) is a specialized membrane that covers the blood vessel in the central nervous system. This structure regulates the passage of certain substances for keeping the homeostasis into the brain. But this selective permeability is a drawback in treatments for neurodegenerative diseases, because the BBB prevents the passage of drugs to the affected brain cells. The use of focused ultrasound (FUS) has proven to be a promising tool for the BBB disruption in specific zones, which improves the release of drugs. One of the problems of FUS is the high attenuation of cranium. This paper presents a study of the acoustic field pattern and the disruption of the BBB in rat's brain for different diameters of craniotomies. These experiments were carried out in rats wistar. A 2 MHz FUS transducer of 10 mm radius and a focal length of 20 mm was used. It was found that a craniotomy of 1 cm allows the focus to be on the substantia nigra, our area of interest, without excessive field distortion and transmission losses. © 2017 IEEE.


Entidades citadas de la UNAM: