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Título del libro: 2016 Global Medical Engineering Physics Exchanges/pan American Health Care Exchanges, Gmepe/pahce 2016
Título del capítulo: Modeling of acoustic field patter in rat's bone with a HIFU transducer for medical experiments in delivery drugs in brain

Autores UNAM:
DANIEL MARTINEZ FONG;
Autores externos:

Idioma:
Inglés
Año de publicación:
2016
Palabras clave:

Acoustics; Biomedical engineering; Bone; Diseases; Finite element method; Health care; Rats; Sonication; Transducers; Ultrasonics; Acoustic pressures; Blood-brain barrier; Controlled release; Focused ultrasound; Medical experiments; Opening-BBB; Piezoelectric; Substantia nigra; Acoustic fields


Resumen:

Currently the controlled release of drugs in specific areas is of great importance for the treatment of diseases such as cancer, Parkinson, Alzheimer and others. This project works with focused ultrasound (HIFU) in rats, more specifically in the application of HIFU in a specific area of the brain called the substantia nigra, in order to generate opening in the membrane of this area called blood-brain barrier (BBB) with the purpose of introducing vectors containing the drug used to treat Parkinson, proposed by the Department of Physiology, Biophysics and Neuroscience Research Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional. This work is the beginning of the investigation based on the modeling of a HIFU transducer in bone tissue of rats weighing approximately 400 gr. In order to obtain the sound field pattern, focus size, pressure and ultrasound path in a time dependent study. All of the above in order to get a clear idea of what you will get when it comes to experimentation. © 2016 IEEE.


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