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SIIA Público
SISTEMA INTEGRAL DE INFORMACIÓN ACADÉMICA - PÚBLICO
Título del libro: Cell Death - Autophagy, Apoptosis And Necrosis Título del capítulo: Steroidal Saponins and Cell Death in Cancer
Steroidal saponins are natural glycosidic compounds of amphiphilic
character. Their diverse biological activities are directly related to
the variability of their structural constitutive frameworks, aglycones,
and sugars. Several studies have demonstrated the therapeutic potential
of steroidal saponins by their capacity to induce programmed cell death
in different tumor cell lines. The process of cell death is required to
maintain cellular and tissular homeostasis; it has been established that
disturbances in the balance between cellular proliferation and cell
death lead to several pathologies, including cancer. The antitumor
activity of steroidal saponins has been intensely studied allowing
elucidation of their different molecular mechanisms of action; this
knowledge is crucial to the establishment of new therapeutic strategies
against cancer.
