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SIIA Público
SISTEMA INTEGRAL DE INFORMACIÓN ACADÉMICA - PÚBLICO
Título del libro: Colorectal Cancer - From Pathogenesis To Treatment Título del capítulo: Molecular Mechanisms Involved in the Acquisition of Resistance to Treatment of Colon Cancer Cells
cancer resistance; autophagy; hypoxia; survival signaling pathways; colon cancer
Resumen:
Cancer cells are remarkably resilient to therapies aimed at their
elimination. The exploration of pathways that sustain cancer cells and
that allow cancer cells to become resistant has revealed new avenues for
chemotherapeutic development, as well as rational approaches to
combination therapies based on existing treatment options. Several
signaling pathways, such as Wnt, phosphoinositide 3-kinase (PI3K), and
Ras-Raf-MEK, constitute integrated networks that work together to
maintain cellular homeostasis under basal conditions and to drive
cell-mass accumulation and cell cycle progression in the presence of
appropriate mitogenic stimuli. During cancer development, these pathways
are corrupted in malignant cells to maintain viability and proliferative
activity under environmentally stressful conditions such as limited
growth factors, oxygen, and nutrients that drive normal cells into
quiescence or death. Importantly, dysfunction within any one of these
pathways results in compensatory responses from the other networks.
Thus, biological research is gradually shifting toward more general
approaches that target entire pathways rather than isolated components
and integrate those pathways into biological networks.
