Título del libro: Tumors Of The Central Nervous System: Astrocytomas, Hemangioblastomas, And Gangliogliomas
Título del capítulo: Role of progesterone receptor isoforms in human astrocytomas growth
IGNACIO CAMACHO ARROYO; VALERIA HANSBERG PASTOR; EDITH ARACELI CABRERA MUÑOZ; OLIVIA TANIA HERNANDEZ HERNANDEZ; ALIESHA ARACELI GONZALEZ ARENAS;
Autores externos:
Idioma:
Inglés
Año de publicación:
2012
Palabras clave:
Brain tumor; Glioma; PR isoforms; Progesterone; Ubiquitin-proteasome system
Resumen:
Progesterone (P) regulates several functions in cells through the interaction with its intracellular receptor (PR), which is a ligand-activated transcription factor that modifies the expression of genes involved in the control of cell growth and proliferation, such as vascular endothelial growth factor and epidermal growth factor receptor. Two PR isoforms have been reported: PR-B and PR-A, encoded by the same gene but with different function and regulation. It has been shown that PR isoforms are expressed in U373 and D54 cell lines, which are derived from grades III and IV of human astrocytomas, respectively. Our group has recently reported that P increases cell growth in both cells lines. The PR antagonist, RU486, blocked P effects and its treatment alone significantly reduced human astrocytomas cell growth in vitro. The over-expression of PR-A in U373 cells significantly reduced P effects. These data suggest that P regulates human astrocytomas cell growth through the interaction with PR and that PR-B/PR-A expression ratio is determinant in P functions in astrocytomas. © Springer Science+Business Media B.V. 2012.
Entidades citadas de la UNAM:
ISBN:
9789400720190
Editorial:
Springer Netherlands Nombre de la publicación:
Role of progesterone receptor isoforms in human astrocytomas growth
Página inicial:
57
Página final:
63
