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Título del libro: Organic Materials As Smart Nanocarriers For Drug Delivery
Título del capítulo: Strategies for the design and synthesis of pincer-based dendrimers

Autores UNAM:
HUGO CHRISTIAN VALDES RIVAS; JUAN MANUEL GERMAN ACACIO; DAVID MORALES MORALES;
Autores externos:

Idioma:
Inglés
Año de publicación:
2018
Palabras clave:

Anticarcinogenic agents; Biomarkers; Bioorganometallic chemistry; Dendrimers; Enhancers of SPR signals; Metallopincer; Pincer compounds; Sensors


Resumen:

The excellent thermal and chemical stability and robustness of ECE-pincer metal complexes make these species promising candidates as medical and therapeutics tools; tools such as: biomarkers, sensors, anticarcinogenic agents, surface plasmon resonance enhancers, etc. In this sense, one of the main interests is the hybridization of organometallic species anchored or incorporated in biological molecules, i.e., mainly in enzymes. Also of interest is the preparation of dendritic ECE-pincer metal complexes as potential drug carriers. Thus far, several papers describing dendrimeric skeletons (e.g., PAMAM) have been reported with promising drug delivery abilities. However, to the best of our knowledge, there are no reports describing the utilization of dendritic ECE-pincer metal complexes as drug carriers. © 2018 Elsevier Inc. All rights reserved.


Entidades citadas de la UNAM: