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Título del libro: Mosaic Of Autoimmunity: The Novel Factors Of Autoimmune Diseases
Título del capítulo: Autoimmune/Inflammatory Syndrome Induced by Adjuvants (Shoenfeld's Syndrome)

Autores UNAM:
LUIS JAVIER JARA QUEZADA; OLGA LIDIA VERA LASTRA; GABRIELA MEDINA GARCIA; MARIA DEL PILAR CRUZ DOMINGUEZ;
Autores externos:

Idioma:
Inglés
Año de publicación:
2019
Palabras clave:

Adjuvant; ASIA; Clinical manifestations; Epidemiology; Molecular mimicry; Treatment


Resumen:

In 2011, Shoenfeld Y and Agmon-Levin described five medical conditions with similar complex of symptoms and signs and a common pathogenesis, namely siliconosis, the Gulf War syndrome, the macrophagic myofasciitis syndrome, postvaccination phenomena, and the sick building syndrome. The authors proposed to gather these five entities under a common syndrome denominated autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Genetically predisposed individuals, the exposure to environmental factors such as silicone, aluminum salts, adjuvant contained in vaccines, mineral oils, collagen, and hyaluronic acid and metal implants are a prerequisite to the appearance of ASIA. The epidemiology of ASIA is unknown; therefore, it is necessary to increase the international database. The immunogenetic, epigenetic, inflammatory mechanisms of each adjuvant and molecular mimicry should continue to be studied. The treatment of ASIA is in agreement with the clinical manifestations and in the identification of risk factors. © 2019 Elsevier Inc. All rights reserved..


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