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Título del libro: Cancer Immunology: A Translational Medicine Context, Second Edition
Título del capítulo: The role of exhaustion in tumor-induced T-cell dysfunction in cancer

Autores UNAM:
HERIBERTO PRADO GARCIA;
Autores externos:
Idioma:
Año de publicación:
2020
Palabras clave:

T-cell dysfunction; T-cell exhaustion; Tumor immunology

Resumen:

T-cells are essential components of the immune system and have been the major focus of immunotherapeutic strategies to boost endogenous antitumor immunity. However, despite homing into tumor sites, infiltrating T-cells seldom control tumor growth, and T-cell-directed immunotherapy has not been successful. Initially, anergy was thought to be responsible for the nonresponsiveness of T-cells to tumors. Nevertheless, cancer has been hypothesized to be a chronic disease, in a similar fashion to chronic viral infections, where T-cells are chronically stimulated. In this scenario, tumor-specific T-cells become dysfunctional, progressively losing effector functions, such as cytolysis or cytokine secretion, a phenomenon known as T-cell exhaustion. In this chapter, we will review the concept of T-cell exhaustion, the mechanisms involved, as well as the markers employed for the identification of exhausted T-cells. To conclude, we discuss the evidence for cancer-induced exhaustion, in particular in lung cancer, in addition to the implications of this phenomenon for tumor immunology. © Springer Nature Switzerland AG 2020.

Entidades citadas de la UNAM:
Fuente:


ISBN:
9783030308452
Editorial:
Springer International Publishing Nombre de la publicación:
The role of exhaustion in tumor-induced T-cell dysfunction in cancer
Página inicial:
117
Página final:
132

Tipo de producto:
Capítulo de un Libro



DOI:
10.1007/978-3-030-30845-2_8