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Título del libro: Cancer Immunology: A Translational Medicine Context, Second Edition
Título del capítulo: T-cell metabolism and its dysfunction induced by cancer

Autores UNAM:
HERIBERTO PRADO GARCIA; ROSALINDA SANDOVAL MARTINEZ;
Autores externos:

Idioma:

Año de publicación:
2020
Palabras clave:

Immunology; Metabolism; Proliferation; T-cell maturation; Tumor


Resumen:

This chapter is focused on the changes in the metabolic pathways of immune cells to fulfill the demands of development, proliferation, and effector function of T-cells. We review how T-cells change their metabolism to (a) obtain energy throughout the different states of maturation (naive, memory, and effector cell), (b) form construction blocks to proliferate (carbon skeleton and nitrogen for nitrogen bases), and (c) live during a long-term period. Finally, we also review how the metabolism of T-cell is affected by the tumor microenvironment. © Springer Nature Switzerland AG 2020.


Entidades citadas de la UNAM: