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Título del libro: The Behavioral, Molecular, Pharmacological, And Clinical Basis Of The Sleep-Wake Cycle
Título del capítulo: Sleep disorders and genes

Autores UNAM:
ERIC SIMON MURILLO RODRIGUEZ; LIRIA TATSUKO YAMAMOTO KIMURA;
Autores externos:

Idioma:

Año de publicación:
2019
Palabras clave:

CRISPR-cas9; Gene; Insomnia; Narcolepsy; Restless legs syndrome; Sleep-wake cycle


Resumen:

The sleep-wake cycle is a neurobiological phenomenon that shows intervals of activity alternating with restfulness that appears with a periodicity approximating the 24-hour day-night cycle. The sleep-wake cycle is under the control of diverse neuroanatomical and neurochemical systems, including monoaminergic, cholinergic, adenosinergic among many other systems. In addition, neuroanatomical centers linked to sleep promotion, such as the hypothalamus, project to the cerebral cortex, subcortical relays, and brainstem. In addition, the sleep-wake cycle has been associated to aberrant features known as sleep disorders. Here, we will discuss the role of specific gene expression on sleep disturbances. Given the expansion of the knowledge in the sleep-wake cycle area, it is indeed ambitious to describe all the genetics involved in the sleep modulation. However, in this chapter we reviewed the current understanding of the sleep disorders and gene expression. © 2019 Elsevier Inc. All rights reserved.


Entidades citadas de la UNAM: