Título del libro: Estrogen Receptors: Structure, Functions And Clinical Aspects
Título del capítulo: Molecular mechanisms that modulate the activity of estrogen receptor alpha in breast cancer
ANGELES CONCEPCION TECALCO CRUZ; MARINA MACIAS SILVA; JOSUE ORLANDO RAMIREZ JARQUIN;
Autores externos:
Idioma:
Año de publicación:
2020
Palabras clave:
Breast cancer; Estrogen receptor alpha; Gene expression; Nuclear export; Stability
Resumen:
Estrogen receptor alpha (ERa) has a central role in the progression of mammary tumors. More than 70% of all cases of breast cancer are ERa positive (ERa+). ERa is a nuclear receptor that is shuffling between the cytoplasm and the nucleus, acting as a signaling mediator out of the nucleus (in the cytoplasm and the cell membrane), and as a transcriptional regulator in the nucleus. Estradiol hormone binds and activates ERa, whereas the ERa phosphorylation induced by growth factors, as epidermal growth factor (EGF) and insulin growth factor (IGF), can also lead to its activation in breast cancer cells. The ERa activity is associated with mammary tumor growth, and consequently, some drugs are directed to control the abundance and/or activity of this receptor. Although these therapeutic strategies function well in some cases, some patients develop resistance to these treatments, which may be associated with the signaling of ERa. In the last years, several studies have decoded different molecular mechanisms that modulate the ERa activity in breast cancer cells via recruiting different transcriptional co-regulators, but also through mechanisms that modulate its stability and the subcellular localization. Interestingly, these mechanisms are also affected by mutations or posttranslational modifications in the ERa. The knowledge of the molecular mechanisms that regulate ERa activity is important in the identification of new biomarkers and therapeutic targets for detecting and controlling the progression of breast cancer. © 2020 Nova Science Publishers, Inc.
Entidades citadas de la UNAM:
ISBN:
9781536182965
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
Molecular mechanisms that modulate the activity of estrogen receptor alpha in breast cancer
Página inicial:
23
Página final:
51
Tipo de producto:
Capítulo de un Libro
