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Título del libro: Estrogen Receptors: Structure, Functions And Clinical Aspects
Título del capítulo: Estrogen signaling pathway in lung cancer and its impact on therapy

Autores UNAM:
VIANEY RODRIGUEZ LARA;
Autores externos:

Idioma:

Año de publicación:
2020
Palabras clave:

Anti-hormonal therapy; Estrogen; Lung cancer; Women


Resumen:

Lung cancer is the leading cause of cancer related-deaths worldwide. Nowadays, lung adenocarcinoma (ADC) is the most common type of lung cancers. Recently, it has been recognized that lung ADC is a hormonedependent cancer, and estrogens play an important role in lung carcinogenesis and tumor progression. The high expression of aromatase enzyme as well as estrogen receptor beta has been identified in lung ADC tissues from men and female patients. The expression of both proteins has been associated with worse prognosis and poor survival in patients with lung ADC. Estrogen promotes lung carcinogenesis by activating several signaling pathways and promoting the expression of genes mainly related to growth factors and involved with cell proliferation and cell cycle. Although some mechanisms of estrogens in lung carcinogenesis have been identified, the role of these hormones in lung cancer continues to be investigated. Because of the relevance of the estrogen in lung cancer, the use of antiestrogenic therapy has been considered in lung cancer treatment. There are currently ten clinical trials in process to test the efficacy of this kind of the therapy in lung cancer, hoping that anti-hormonal therapy will be applied in lung cancer treatment in the future. © 2020 Nova Science Publishers, Inc.


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