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SIIA Público
SISTEMA INTEGRAL DE INFORMACIÓN ACADÉMICA - PÚBLICO
Título del libro: Antiprotozoal Drug Discovery: A Challenge That Remains Título del capítulo: Crude Extracts and Isolated Compounds with Trypanocidal Activity
Chagas' disease, or American trypanosomiasis, is a potentially mortal
disease caused by the protozoan Trypanosoma cruzi. It is included in the
list of neglected diseases or poverty-linked diseases. An estimate of
5.7 million people in the endemic areas are infected, resulting in 7000
yearly deaths. The disease is distributed in Central and South America,
Mexico, and the southern United States. Due to rural-urban migration,
the parasite is transmitted by blood transfusion, by vertical
transmission from mother to child, or by organ transplantation; on the
other side, some cases have been detected in non-endemic zones both in
America and in Europe. Chagas' disease is among the 17 neglected
diseases; it is a complex zoonosis, involving interaction of vectors
species with wild, peridomestic, and domestic mammals, showing several
clinical pictures and transmission modes. It poses the highest economic
burden among parasitic diseases in Latin America due to its long
chronicity. The clinical manifestations and epidemiologic traits of the
disease vary from region to region. The current medication against T.
cruzi, nifurtimox and benznidazole, has adverse effects. Aiming to make
new treatment alternatives known, the activity of plant-isolated
compounds from Central America, South America, and Mexico is herein
discussed, along with their action against different stages of
Trypanosoma cruzi.
