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SIIA Público
SISTEMA INTEGRAL DE INFORMACIÓN ACADÉMICA - PÚBLICO
Título del libro: Antiprotozoal Drug Discovery: A Challenge That Remains Título del capítulo: Metals as an Option for Protozoa Treatment
Protozoa infections are a worldwide health problem that preferentially
affects populations in underdeveloped countries. Plasmodium, Leishmania,
Trypanosoma, Toxoplasma, Neospora, Entamoeba and Trichomonas are some of
the most important genuses of protozoan parasites that infect and invade
cells, tissues and organs. These parasites proliferate, migrate and
mutate to evade the chemotherapeutic effects of drugs that were
previously effective for their treatment. The use of metals and metals
complexes to control and treat these parasites, seems a very prominent
alternative. Palladium, platinum, ruthenium, antimonium, gold, iron and
vanadium are some of the metals that have been evaluated as
antiprotozoal treatments with favorable results. A review of the
experimental effects of metal complexes on these parasites follows,
along with commentary.
