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Título del libro: Liver Pathophysiology: Therapies And Antioxidants
Título del capítulo: The Immune System and Viral Hepatitis

Autores UNAM:
NORA ALMA FIERRO GONZALEZ;
Autores externos:

Idioma:
Inglés
Año de publicación:
2017
Palabras clave:

Bilirubin; Cytokines; Gene-environment interactions; Genotype; Heme-related metabolism; Immune cells; Latin America; Lipids; Metabolites; Mexico


Resumen:

Hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis E virus are viruses with hepatotropic lifecycles. Numerous studies have demonstrated the prominent role of the immune system in liver damage caused by these viruses. This chapter introduces the concept that differences in the host immune response dictate the distinct outcomes to these infections. It starts by presenting the natural history of these viral illnesses. A high-level perspective of the cellular immune responses against HAV, HBV, and HCV is included. Recent data pointing at the host (genetic), viral (genotype), and environmental factors that may account for the differential immune response in the admixed Mexican population are underlined. At the end of the chapter, the immune cells, cytokines, and metabolites with immunomodulatory functions related to liver injury are explained. We focus on discoveries that hold promise for identifying immunologic features in the resolution of viral hepatitis. © 2017 Elsevier Inc. All rights reserved.


Entidades citadas de la UNAM: